A simple, accurate, and precise Simultaneous Equation spectrophotometric method was developed for simultaneous determination of Lignocaine and Propofol. The method involves determination of Lignocaine at 224.2-240.6nm and Propofol at 258.6-284nm. Both drugs follow Beer-Lambert’s law over the concentration range of 20-100 μg/ml and 10-50 μg/ml for Lignocaine and Propofol respectively. The % assay of the drugs was found to 98.7±1.63 and % 98.8±1.48 for Lignocaine and Propofol respectively. Validation of the proposed method was carried out for its linearity, accuracy, precision, LOD, and LOQ, according to ICH guidelines. The recovery of the Lignocaine and Propofol were found to 99.33±0.82% and 99.60±0.56% for Lignocaine and Propofol respectively. The proposed methods can be successfully applied in routine work for determination of Lignocaine and Propofol in pharmaceutical dosage form.
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